INTRODUCTION

Fc receptors (FcRs) are glycoproteins of approximate molecular weights of 50-70 kD. They’re extensively expressed
all by means of the immune cells. Fc receptors are present on leukocytes equal to monocytes, tissue macrophages, B cells, granulocytes (eosinophils, basophils, neutrophils), NK cells and some T cells. Fc receptors are moreover present on mast cells, follicular dendritic cells, epithelial cells, endothelial cells, hepatocytes and langerhans cells amongst others. There are a variety of types of Fc receptors (FcR) which can be categorised based on the antibody that they acknowledge. There are individuals who have good affinity for the Fc space of monomeric IgG antibody and are known as Fc-Gamma receptors, individuals who bind to IgA antibody are known as Fc-alpha receptors and individuals who bind IgE antibody are known as Fc-epsilon receptors.

 

Non specific Fc receptors staining in assays equal to IHC, ICC, Immunofluorescence (IF) and motion cytometry might find yourself from the binding of the Fc space of the primary and/or secondary antibody or immunoglobulin isotypes to the Fc receptors of the cells. Eliminating Fc receptor staining is fascinating in IHC, ICC, IF and Circulation cytometry assays for the intention of right info evaluation.
For IHC, ICC, IF testing: The binding of the Fc space of main and/or secondary antibody and immunoglobulin
isotypes to the Fc receptors present on cells/tissues give rise to non-specific Fc receptor staining. Specimens rich in Fc receptors embrace spleen, lymphoid tissues, lymphomas, tonsil, lymph nodes, bone marrow, blood smears and liver. Others embrace tissues and cell preps meant for staining for CD markers; Immunoglobulins (Igs), Kappa and Lambda and tumor cell traces that express Fc receptors. To steer clear of Fc receptor staining; tissue sections and cell preparations are incubated with Innovex Fc Blocker for a quick interval earlier to utility of main antibody or immunoglobulin isotypes (See instruction a part of this info sheet).

 

PRODUCT DESCRIPTION

Innovex Fc Receptor Blocker is a UNIVERSAL Fc Blocker related to blocking all types of Fc receptors equal to Fc-gamma receptors of kind I,II and III; Fc -epsilon receptors kind I and II; Fc –alpha receptors, Fcα/ µR and FcRn. Innovex Fc Blocker does NOT comprise antibodies, Immunoglobulins or immunoglobulin fragments. INNOVEX Fc Blocker could be universally utilized to dam all types of Fc receptors in all-species along with human, mouse and all-animals This Widespread Fc Block might be utilized in a variety of Immunoassays equal to IHC, ICC, Immunofluorescence and Circulation cytometry. INNOVEX UNIVERSAL Fc BLOCK is acceptable for blocking Fc receptors in frozen and paraffin tissuesections and cyto preps of human and all-animal species. INNOVEX Fc Blocker may also be usually used for eliminating background staining in thoughts cells/tissues.

For Circulation cytometry assays: Fc receptors are present on leukocytes (white blood cells), many cell traces along with completely different
cell varieties in every human and animal cells/tissues. Fc receptors provides rise to non-specific Fc receptor-staining in motion
cytometry assays by binding of Fc space of antibodies and isotype controls to Fc receptors of the cells. Non-specific Fc receptors staining could be eradicated by incubating cells with INNOVEX Fc Receptor Blocker for a variety of Circulation cytometry assays equal to CD phenotyping, leukemia typing and cell line analysis. (See instruction a part of this info sheet).

 

Universal Casein Diluent/Blocker
85R-108	Fitzgerald	250 ml	EUR 276
Description: Ready-to-use biotin free reagent applicable for blocking ELISA plates

Azide Free Fc Receptor Blocker NEW
NB335-60	Innovex	60 ml	EUR 1027.2

Universal IHC Diluent/Blocker/Stabilizer
85R-1021	Fitzgerald	1 liter	EUR 830.4
Description: Universal Diluent/Blocker/Stabilizer for use in IHC

Fc Receptor Blocker; 4X Concentrate, 15ml NEW
NB309-4X-15	Innovex	15 ml of 4X	EUR 930

Enhanced Universal IHC Diluent/Blocker/Stabilizer
85R-1021E	Fitzgerald	100 ml	EUR 224.4
Description: Enhanced Universal Diluent/Blocker/Stabilizer for use in IHC

Azide Free Fc Rreceptor Blocker
NB335	Innovex	30 ml	EUR 651.6

Sheep IgG-Fc ELISA Kit, 96 tests, Quantitative
7615-Fc	Alpha Diagnostics	1 kit	EUR 854.4

Horse IgG-Fc ELISA Kit, 96 tests, Quantitative
7715-Fc	Alpha Diagnostics	1 kit	EUR 854.4

Dog IgG (Fc) fragment (isotype control, non-immune), purified
20016-FC	Alpha Diagnostics	0.5 mg	EUR 300

Human IgG (Fc) fragment, purified
20007-1-FC	Alpha Diagnostics	0.5 mg	EUR 249.6

Mouse IgG (Fc) fragment, purified
20008-1-FC	Alpha Diagnostics	0.5 mg	EUR 300

Rabbit IgG (Fc) fragment, purified
20009-1-FC	Alpha Diagnostics	0.5 mg	EUR 300

Goat IgG (Fc) fragment, purified
20011-1-FC	Alpha Diagnostics	0.5 mg	EUR 300

Rat IgG (Fc) fragment, purified (isotype control)
20005-1-FC	Alpha Diagnostics	0.5 mg	EUR 300

Goat IgG (fc)-Biotin conjugate (isotype control)
20011-Fc-B	Alpha Diagnostics	100 ug	EUR 196.8

Goat IgG (fc)-FITC conjugate (isotype control)
20011-Fc-F	Alpha Diagnostics	100 ug	EUR 196.8

Goat IgG (fc)-HRP conjugate (isotype control)
20011-Fc-HP	Alpha Diagnostics	100 ug	EUR 196.8

Hen Blocker
CH23106	Neuromics	100 ml	EUR 434.4

Dog IgG (Fc) fragment (isotype control, non-immune), purified
20016-3-FC	Alpha Diagnostics	0.5 mg	EUR 300

Dog IgG Fc-Biotin Conjugate (isotype control, non-immune), purified
20016-FC-B	Alpha Diagnostics	0.1 mg	EUR 270

Dog IgG Fc-FITC Conjugate (isotype control, non-immune), purified
20016-FC-F	Alpha Diagnostics	0.1 mg	EUR 270

Dog IgG Fc-HRP Conjugate (isotype control, non-immune), purified
20016-FC-HP	Alpha Diagnostics	0.1 mg	EUR 270

Bax channel blocker
A4459-10	ApexBio	10 mg	EUR 408
Description: IC50: 0.52 ?M in Bax assayBax channel blocker is an inhibitor of Bax-mediated mitochondrial cytochrome c release.

Bax channel blocker
A4459-50	ApexBio	50 mg	EUR 1531.2
Description: IC50: 0.52 ?M in Bax assayBax channel blocker is an inhibitor of Bax-mediated mitochondrial cytochrome c release.

Active Blocker 2
abx090802-01g	Abbexa	0.1 g	EUR 594

Active Blocker 3
abx090803-01g	Abbexa	0.1 g	EUR 493.2

Active Blocker 1
abx090804-01g	Abbexa	0.1 g	EUR 718.8

BCTC (TRPV1 blocker)
SIH-307-10MG	Stressmarq	10 mg	EUR 242.4
Description: The substance BCTC is a trpv1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 40 mM in ethanol.

BCTC (TRPV1 blocker)
SIH-307-50MG	Stressmarq	50 mg	EUR 450
Description: The substance BCTC is a trpv1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 40 mM in ethanol.

Recombinant (HEK) Human IgG3-Fc (99-377aa, His-tag, >95%, low endotoxin)
20007-G3-FC	Alpha Diagnostics	50 ug	EUR 343.2

Rat IgG (Fc)-Biotin Conjuagte (isotype control), purified
20005-1-FC-B	Alpha Diagnostics	0.1 mg	EUR 270

Rat IgG (Fc)-FITC Conjuagte (isotype control), purified
20005-1-FC-F	Alpha Diagnostics	0.1 mg	EUR 270

Rat IgG (Fc)-HRP Conjuagte (isotype control), purified
20005-1-FC-HP	Alpha Diagnostics	0.1 mg	EUR 270

Human IgG (Fc) fragment, purified (>95%, low endotoxin)
20007-1-FC-LE	Alpha Diagnostics	100 ul	EUR 270

Recombinant (HEK) Mouse IgG2a-Fc (98-330aa, ~34 kda, His-tag, >95%, low endotoxin)
20102-102-FC	Alpha Diagnostics	50 ug	EUR 343.2

Recombinant (HEK) Mouse IgG2b-Fc (97-335aa, ~37 kda, His-tag, >95%, low endotoxin)
20102-103-FC	Alpha Diagnostics	50 ug	EUR 343.2

Recombinant (HEK) Mouse IgG3-Fc (97-329aa, ~33 kda, His-tag, >95%, low endotoxin)
20102-104-FC	Alpha Diagnostics	50 ug	EUR 343.2

Recombinant (HEK) Human IgG1 Fc (103Cys/Ser, 99-330aa, His-tag, >95%, low endotoxin)
20007-G1-FC	Alpha Diagnostics	50 ug	EUR 343.2