INTRODUCTION
Fc receptors (FcRs) are glycoproteins of approximate molecular weights of 50-70 kD. They’re extensively expressed
all by means of the immune cells. Fc receptors are present on leukocytes equal to monocytes, tissue macrophages, B cells, granulocytes (eosinophils, basophils, neutrophils), NK cells and some T cells. Fc receptors are moreover present on mast cells, follicular dendritic cells, epithelial cells, endothelial cells, hepatocytes and langerhans cells amongst others. There are a variety of types of Fc receptors (FcR) which can be categorised based on the antibody that they acknowledge. There are individuals who have good affinity for the Fc space of monomeric IgG antibody and are known as Fc-Gamma receptors, individuals who bind to IgA antibody are known as Fc-alpha receptors and individuals who bind IgE antibody are known as Fc-epsilon receptors.
Non specific Fc receptors staining in assays equal to IHC, ICC, Immunofluorescence (IF) and motion cytometry might find yourself from the binding of the Fc space of the primary and/or secondary antibody or immunoglobulin isotypes to the Fc receptors of the cells. Eliminating Fc receptor staining is fascinating in IHC, ICC, IF and Circulation cytometry assays for the intention of right info evaluation.
For IHC, ICC, IF testing: The binding of the Fc space of main and/or secondary antibody and immunoglobulin
isotypes to the Fc receptors present on cells/tissues give rise to non-specific Fc receptor staining. Specimens rich in Fc receptors embrace spleen, lymphoid tissues, lymphomas, tonsil, lymph nodes, bone marrow, blood smears and liver. Others embrace tissues and cell preps meant for staining for CD markers; Immunoglobulins (Igs), Kappa and Lambda and tumor cell traces that express Fc receptors. To steer clear of Fc receptor staining; tissue sections and cell preparations are incubated with Innovex Fc Blocker for a quick interval earlier to utility of main antibody or immunoglobulin isotypes (See instruction a part of this info sheet).
PRODUCT DESCRIPTION
Innovex Fc Receptor Blocker is a UNIVERSAL Fc Blocker related to blocking all types of Fc receptors equal to Fc-gamma receptors of kind I,II and III; Fc -epsilon receptors kind I and II; Fc –alpha receptors, Fcα/ µR and FcRn. Innovex Fc Blocker does NOT comprise antibodies, Immunoglobulins or immunoglobulin fragments. INNOVEX Fc Blocker could be universally utilized to dam all types of Fc receptors in all-species along with human, mouse and all-animals This Widespread Fc Block might be utilized in a variety of Immunoassays equal to IHC, ICC, Immunofluorescence and Circulation cytometry. INNOVEX UNIVERSAL Fc BLOCK is acceptable for blocking Fc receptors in frozen and paraffin tissuesections and cyto preps of human and all-animal species. INNOVEX Fc Blocker may also be usually used for eliminating background staining in thoughts cells/tissues.
For Circulation cytometry assays: Fc receptors are present on leukocytes (white blood cells), many cell traces along with completely different
cell varieties in every human and animal cells/tissues. Fc receptors provides rise to non-specific Fc receptor-staining in motion
cytometry assays by binding of Fc space of antibodies and isotype controls to Fc receptors of the cells. Non-specific Fc receptors staining could be eradicated by incubating cells with INNOVEX Fc Receptor Blocker for a variety of Circulation cytometry assays equal to CD phenotyping, leukemia typing and cell line analysis. (See instruction a part of this info sheet).
 Universal Casein Diluent/Blocker |
|||
| 85R-108 | Fitzgerald | 250 ml | EUR 230 |
|
Description: Ready-to-use biotin free reagent applicable for blocking ELISA plates |
|||
 Universal IHC Diluent/Blocker/Stabilizer |
|||
| 85R-1021 | Fitzgerald | 1 liter | EUR 692 |
|
Description: Universal Diluent/Blocker/Stabilizer for use in IHC |
|||
 Azide Free Fc Receptor Blocker NEW |
|||
| NB335-60 | Innovex | 60 ml | EUR 856 |
 Enhanced Universal IHC Diluent/Blocker/Stabilizer |
|||
| 85R-1021E | Fitzgerald | 100 ml | EUR 187 |
|
Description: Enhanced Universal Diluent/Blocker/Stabilizer for use in IHC |
|||
 Fc Receptor Blocker; 4X Concentrate, 15ml NEW |
|||
| NB309-4X-15 | Innovex | 15 ml of 4X | EUR 775 |
 Azide Free Fc Rreceptor Blocker |
|||
| NB335 | Innovex | 30 ml | EUR 543 |
 Sheep IgG-Fc ELISA Kit, 96 tests, Quantitative |
|||
| 7615-Fc | Alpha Diagnostics | 1 kit | EUR 712 |
 Horse IgG-Fc ELISA Kit, 96 tests, Quantitative |
|||
| 7715-Fc | Alpha Diagnostics | 1 kit | EUR 712 |
 fragment (isotype control, non-immune), purified) Dog IgG (Fc) fragment (isotype control, non-immune), purified |
|||
| 20016-FC | Alpha Diagnostics | 0.5 mg | EUR 250 |
 fragment, purified) Human IgG (Fc) fragment, purified |
|||
| 20007-1-FC | Alpha Diagnostics | 0.5 mg | EUR 208 |
 fragment, purified) Mouse IgG (Fc) fragment, purified |
|||
| 20008-1-FC | Alpha Diagnostics | 0.5 mg | EUR 250 |
 fragment, purified) Rabbit IgG (Fc) fragment, purified |
|||
| 20009-1-FC | Alpha Diagnostics | 0.5 mg | EUR 250 |
 fragment, purified) Goat IgG (Fc) fragment, purified |
|||
| 20011-1-FC | Alpha Diagnostics | 0.5 mg | EUR 250 |
 Hen Blocker |
|||
| CH23106 | Neuromics | 100 ml | EUR 362 |
 fragment, purified (isotype control)) Rat IgG (Fc) fragment, purified (isotype control) |
|||
| 20005-1-FC | Alpha Diagnostics | 0.5 mg | EUR 250 |
-Biotin conjugate (isotype control)) Goat IgG (fc)-Biotin conjugate (isotype control) |
|||
| 20011-Fc-B | Alpha Diagnostics | 100 ug | EUR 164 |
-FITC conjugate (isotype control)) Goat IgG (fc)-FITC conjugate (isotype control) |
|||
| 20011-Fc-F | Alpha Diagnostics | 100 ug | EUR 164 |
-HRP conjugate (isotype control)) Goat IgG (fc)-HRP conjugate (isotype control) |
|||
| 20011-Fc-HP | Alpha Diagnostics | 100 ug | EUR 164 |
) BCTC (TRPV1 blocker) |
|||
| SIH-307-10MG | Stressmarq | 10 mg | EUR 202 |
|
Description: The substance BCTC is a trpv1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 40 mM in ethanol. |
|||
BCTC (TRPV1 blocker) |
|||
| SIH-307-50MG | Stressmarq | 50 mg | EUR 375 |
|
Description: The substance BCTC is a trpv1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 40 mM in ethanol. |
|||
 Active Blocker 2 |
|||
| abx090802-01g | Abbexa | 0.1 g | EUR 495 |
 Active Blocker 3 |
|||
| abx090803-01g | Abbexa | 0.1 g | EUR 411 |
 Active Blocker 1 |
|||
| abx090804-01g | Abbexa | 0.1 g | EUR 599 |
 Bax channel blocker |
|||
| A4459-10 | ApexBio | 10 mg | EUR 340 |
|
Description: IC50: 0.52 ?M in Bax assayBax channel blocker is an inhibitor of Bax-mediated mitochondrial cytochrome c release. |
|||
Bax channel blocker |
|||
| A4459-50 | ApexBio | 50 mg | EUR 1276 |
|
Description: IC50: 0.52 ?M in Bax assayBax channel blocker is an inhibitor of Bax-mediated mitochondrial cytochrome c release. |
|||
Dog IgG (Fc) fragment (isotype control, non-immune), purified |
|||
| 20016-3-FC | Alpha Diagnostics | 0.5 mg | EUR 250 |
, purified) Dog IgG Fc-Biotin Conjugate (isotype control, non-immune), purified |
|||
| 20016-FC-B | Alpha Diagnostics | 0.1 mg | EUR 225 |
, purified) Dog IgG Fc-FITC Conjugate (isotype control, non-immune), purified |
|||
| 20016-FC-F | Alpha Diagnostics | 0.1 mg | EUR 225 |
, purified) Dog IgG Fc-HRP Conjugate (isotype control, non-immune), purified |
|||
| 20016-FC-HP | Alpha Diagnostics | 0.1 mg | EUR 225 |
 UNIVERSAL PLATFORM |
|||
| 480144 | CORNING | 1/pk | EUR 269 |
|
Description: Lab Equipment; Constant Temperature Equipment |
|||
) Cyclopamine (Hedgehog signaling blocker) |
|||
| SIH-226-1MG | Stressmarq | 1 mg | EUR 135 |
|
Description: The substance Cyclopamine is a hedgehog signaling blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 5 mM in ethanol. |
|||
Cyclopamine (Hedgehog signaling blocker) |
|||
| SIH-226-5MG | Stressmarq | 5 mg | EUR 345 |
|
Description: The substance Cyclopamine is a hedgehog signaling blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 5 mM in ethanol. |
|||
) A-967079 (TRPA1 blocker) |
|||
| SIH-301-10MG | Stressmarq | 10 mg | EUR 179 |
|
Description: The substance A-967079 is a trpa1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in DMSO (25 mg/ml). |
|||
A-967079 (TRPA1 blocker) |
|||
| SIH-301-50MG | Stressmarq | 50 mg | EUR 490 |
|
Description: The substance A-967079 is a trpa1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in DMSO (25 mg/ml). |
|||
) Astemizole (Herg channel blocker) |
|||
| SIH-302-10MG | Stressmarq | 10 mg | EUR 133 |
|
Description: The substance Astemizole is a herg channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 25 mM in ethanol. |
|||
Astemizole (Herg channel blocker) |
|||
| SIH-302-50MG | Stressmarq | 50 mg | EUR 329 |
|
Description: The substance Astemizole is a herg channel blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO and to 25 mM in ethanol. |
|||
) HC-030031 (TRPA1 blocker) |
|||
| SIH-303-10MG | Stressmarq | 10 mg | EUR 144 |
|
Description: The substance HC-030031 is a trpa1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO. |
|||
HC-030031 (TRPA1 blocker) |
|||
| SIH-303-50MG | Stressmarq | 50 mg | EUR 386 |
|
Description: The substance HC-030031 is a trpa1 blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 100 mM in DMSO. |
|||